Potentially Lethal Damage Repair and Sublethal Damage Repair After Proton Beam Irradiation: Comparison With X-ray Treatment
نویسندگان
چکیده
منابع مشابه
Repair of potentially lethal damage in vivo in solid tumor cells after x-irradiation.
The survival of cells from two transplantable murine tumors (NCTC 2472 fibrosarcoma and EMT6 mammary sarcoma), X-irradiated in vivo, was assayed by determining the clonogenicity of the cells in vitro. Cells from tumors kept in situ 6 or 24 hr after irradiation had higher survival than cells from tumors excised immediately after irradia tion. This increase in survival was done dependent and had ...
متن کاملThe mitochondria-targeted nitroxide JP4-039 augments potentially lethal irradiation damage repair.
It was unknown if a mitochondria-targeted nitroxide (JP4-039) could augment potentially lethal damage repair (PLDR) of cells in quiescence. We evaluated 32D cl 3 murine hematopoietic progenitor cells which were irradiated and then either centrifuged to pellets (to simulate PLDR conditions) or left in exponential growth for 0, 24, 48 or 72 h. Pelleted cells demonstrated cell cycle arrest with a ...
متن کاملRepair of cellular damage after high LET irradiation.
There is evidence for slower/less repair in many cellular systems after high LET compared to after low LET irradiation. In tissues, this includes both early and late reactions, as well as residual injury characterised by a low re-irradiation tolerance . Such effects in tissues are reflected by responses of the target cells responsible for injury, for example in intestine, bone marrow, epidermis...
متن کاملDecay of γ-H2AX foci correlates with potentially lethal damage repair in prostate cancer cells.
To determine the relationship between ionizing radiation-induced levels of γ-H2AX foci and cell survival in cultured prostate cancer cell lines, three prostate cancer cell lines: LNCaP (wt TP53), DU145 (mut TP53) and PC3 (TP53 null), were studied. For γ-H2AX foci induction, cells were irradiated with a single dose of 2 Gy and foci levels were studied at 30 min and 24 h after irradiation. Cell s...
متن کاملRepair of soft X-ray damage to mammalian cell DNA.
[a-Z'P]ddATP ( I pCi) was added to cuvettes followed by 0.8 ml of cell suspension ( 1 0' cells). ( 0 ) after permeabilization cells were irradiated with I00 J m ? 248 nm light and the incubations quenched at the times shown by the addition of 0.5 ml o f 5 M-NaOH. ( m ) No 248 nm U.V. fact greatly increased the size of the initial peak of the incorporation of ['HITTP and [ "PITTP. It therefore s...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: International Journal of Radiation Oncology*Biology*Physics
سال: 2016
ISSN: 0360-3016
DOI: 10.1016/j.ijrobp.2016.06.2058